Base‐Promoted Synthesis of Polysubstituted 4‐Aminoquinolines from Ynones and 2‐Aminobenzonitriles under Transition‐Metal‐Free Conditions
نویسندگان
چکیده
A transition-metal-free and base-promoted one-pot reaction of ynones with 2-aminobenzonitriles is described. The was initiated through sequential aza-Michael addition/intramolecular annulation to afford various multisubstituted 4-aminoquinolines 4-amino-1,8-naphthyridines in good excellent yields. Operational simplicity, high atom-economy broad substrate scope makes this protocol more attractive. Also, the gram-scale synthesis further transformation product were studied. Additionally, 2-haloarylyones as provide N-arylquinolones sole via SNAr mechanism.
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ژورنال
عنوان ژورنال: Advanced Synthesis & Catalysis
سال: 2021
ISSN: ['1615-4169', '1615-4150']
DOI: https://doi.org/10.1002/adsc.202100023